Autophagy is a cellular process allowing the clearance or recycling of intracellular constituents. It is a ubiquitous catabolic pathway that is highly conserved among eukaryotes. It was first identified shortly after Christian de Duve discovered lysosomes in the early 60's (Nobel Prize for Medicine and physiology in 1974). To date, three major pathways have been identified : the chaperonne-mediated selective autophagy of cytosolic proteins and membranes, the autophagic degradation of portions of the cytoplasm, and the selective autophagic degradation of intracellular organelles and of invading microorganisms. Autophagy has emerged over the last decade as a fundamental phenomenon for the regulation of homeostasis at the cellular level as well as the level of whole organisms, and its dysregulation is associated to numerous pathologies. Autophagy has consequently become a growing field of investigation, and a major stake in basic sciences like biology, physiology, neurology, infection and immunology for the discovery of new therapeutic agents. Cancer, neurodenegerative diseases (e.g. Parkinson), autoimmune (e.g. lupus) and inflammatory (e.g. Crohn) diseases are among the pathologies related to autophagy defects. The Club Francophone de l'AuTophaGie (CFATG) was created in 2010, to promote the scientific research on autophagy, to foster communication between French scientists with a special emphasis on promoting youngsters. The 6th edition of the meeting will span over 3 days with both French and international attendees, and will be another occasion to gather the autophagy communities from France and Europe.

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